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New virus strain more infective

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New virus strain more infective

Reports from Britain and South Africa of new coronavirus strains that seem to spread more easily are causing alarm, but virus experts say it’s unclear if that’s the case or whether they pose any concern for vaccines or cause more severe diseases.

Viruses naturally evolve as they move through the population, some more than others. It’s one reason we need a fresh flu shot each year.

New variants or strains of the virus that causes Covid-19 have been seen almost since it was first detected in China nearly a year ago.

Britain’s Prime Minister Boris Johnson attends a virtual press conference inside 10 Downing Street in central London on December 19, 2020. British Prime Minister Boris Johnson on Saturday announced a “stay at home” order for London and southeast England to slow a new coronavirus strain that is significantly more infectious. The new strain of the virus “does appear to be passed on significantly more easily,” Johnson said at a televised briefing. He ordered new restrictions for London and south-eastern England from Sunday, saying that under the new “tier four” rules, “residents in those areas must stay at home” at least until December 30. / AFP / POOL / TOBY MELVILLE

On Saturday, Prime Minister Boris Johnson announced new restrictions because of the new strain. Several European Union countries and Canada were banning or limiting some flights from the United Kingdom to try to limit any spread.

Health experts in the UK and the United States said the strain seems to infect more easily than others, but there is no evidence yet it is more deadly.

Patrick Vallance, the British government’s chief scientific adviser, said that the strain “moves fast and is becoming the dominant variant,” causing over 60 percent of infections in London by December.

The strain is also concerning because it has so many mutations — nearly two dozen — and some are on the spiky protein that the virus uses to attach to and infect cells. That spike is what current vaccines target.

“I’m worried about this, for sure,” but it’s too soon to know how important it ultimately will prove to be, said Dr. Ravi Gupta, who studies viruses at the University of Cambridge in England.

Viruses often acquire small changes of a letter or two in their genetic alphabet just through normal evolution. A slightly modified strain can become the most common one in a country or region just because that’s the strain that first took hold there or because “super spreader” events helped it become entrenched.

A bigger worry is when a virus mutates by changing the proteins on its surface to help it escape from drugs or the immune system.

“Emerging evidence” suggests that may be starting to happen with the new coronavirus, Trevor Bedford, a biologist and genetics expert at the Fred Hutchinson Cancer Research Center in Seattle, wrote on Twitter. “We’ve now seen the emergence and spread of several variants” that suggest this, and some show resistance to antibody treatments, he noted.

In April, researchers in Sweden found a virus with two genetic changes that seemed to make it roughly two times more infectious, Gupta said. About 6,000 cases worldwide have been reported, mostly in Denmark and England, he said.

Several variations of that strain now have turned up. Some were reported in people who got them from mink farms in Denmark. A new South African strain has the two changes seen before, plus some others.

The one in the UK has the two changes and more, including eight to the spike protein, Gupta said. It’s called a “variant under investigation” because its significance is not yet known.

The strain was identified in southeastern England in September and has been circulating in the area ever since, a World Health Organization official told the BBC on Sunday.

President-elect Joe Biden’s surgeon general nominee, Vivek Murthy, said Sunday on NBC’s “Meet the Press” that there’s “no reason to believe that the vaccines that have been developed will not be effective against this virus as well.”

Vaccines produce wide-ranging responses by the immune system beyond just those to the spike protein, several experts noted.

The possibility that new strains will be resistant to existing vaccines are low, but not “inexistent,” Dr. Moncef Slaoui, the chief science adviser for the US government’s vaccine distribution effort, said.

“Up to now, I don’t think there has been a single variant that would be resistant,” he said. “This particular variant in the UK, I think, is very unlikely to have escaped the vaccine immunity.”

Not in the Philippines

The strain that was discovered in the UK has not entered the country yet, according to the Research Institute for Tropical Medicine (RITM).

Health Undersecretary Maria Rosario Vergeire on Monday said the RITM has not received any report of any new strain of Covid-19.

Vergeire said the Philippines has imposed restrictions on arriving foreigners. Only those with diplomatic or official business are allowed.

On Monday, the Philippines logged 1,721 new cases of Covid-19, pushing the total to 461,505, of which 23,341 were active.

WITH RED MENDOZA

   

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